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Sage — Music as Temporal Coherence
The Shore · Circadian
Music may not be an external ornament applied to an already-constituted organism. It may be pure temporal patterning that requires no external semantic referent. Its intelligibility may be the structure of coherence itself.
Music appears in every human society studied, and across cultures the sound of a song reliably signals its context: soothing an infant, dancing, healing (Mehr et al. 2019). Whether the preference for simple-ratio 'consonant' intervals is built in is less clear; one study of a remote Amazonian community found no such preference, suggesting culture plays a large part (McDermott et al. 2016).
Bach’s counterpoint may supply the clearest example of many independent lines held together in one order. Counterpoint does not collapse into monophony nor dissolve into noise. In his first two or three years at Leipzig, Bach produced new cantatas at a remarkable pace, at times one a week (Marshall 2026); his annual cantata cycles date mainly from 1723–25 (Schulze 2024). That pace is the practical counterpart: excellence as trained habit.
Active musical performance by a living performer may work as continuous prediction and correction: the performer keeps predicting the next sound, hears the error, and corrects it in real time. Listening supplies an external pattern to which the body may entrain. Performance closes the loop: prediction, error, and correction occur inside the same medium that is being shaped.
Short-scale acoustic patterning may preferentially modulate fast systems; longer-scale nested patterning may entrain slower systems. A single interval or phrase is a short-scale coherence event; a movement is a longer-scale nesting of those events. Bach’s counterpoint already contains nested timescales.
What the studies show so far
In kennelled dogs, classical music has been linked to higher heart-rate variability and more time lying quietly, although dogs got used to it within days (Bowman et al. 2015). Smaller studies in horses, cats and rodents report calming effects that vary with species, the kind of music and the setting (Wiśniewska et al. 2019; Hampton et al. 2020; Kühlmann et al. 2018), so a single shared physiological signature across species has not been shown.
In one small cell-culture study, a recording of Chinese five-element music was reported to raise ATP and glutathione and lower reactive oxygen species in a single human kidney cell line (HEK293T), while heavy-metal music had the opposite effect on oxidative stress; classical music changed cell growth but not ATP or ROS (Feng et al. 2022). These are early, unreplicated laboratory findings, and they do not show that listening to music changes cellular energy in the body.
Small studies suggest that older adults who take up an instrument may better preserve some aspects of working memory and brain structure. In one small, non-randomized four-year follow-up, those who kept playing held up better than those who stopped (Wang et al. 2025), though in the largest randomized trial a music-listening course produced similar gains (Marie et al. 2023), and reviews call the evidence preliminary (Espinosa et al. 2025). Wind players have been reported to have stronger breathing measures than population norms (Darabseh et al. 2026), and singing groups may help some people with chronic lung disease feel better (McNamara et al. 2017), but trials are few and small. One small study using near-infrared spectroscopy found higher oxidative (mitochondrial) capacity in the forearm muscles that move the ring and little fingers in eight pianists than in non-players, consistent with a local training effect, though it compared groups at one point in time rather than following people as they learned (Luquire & McCully 2019).
Studies of music listening more often report short-term changes in heart-rate variability than consistent changes in cortisol (Mojtabavi et al. 2020; de Witte et al. 2020), although much of this research is small and at risk of bias, and some reviews find no reliable effect at all (Adiasto et al. 2022).
Light is the body clock's main time cue, but in two small laboratory studies from one research group, a recording of bird song with a classical-music background shifted the timing of the melatonin and core-temperature rhythms by about an hour: later when played during the biological night, earlier when played in the biological morning (Goel 2005; Goel 2006). It is not yet clear whether the sound acted on the clock itself or worked by keeping people alert, and the finding has not been widely replicated.
Reference: Adiasto K, Beckers DGJ, van Hooff MLM, Roelofs K, Geurts SAE. Music listening and stress recovery in healthy individuals: a systematic review with meta-analysis of experimental studies. PLoS One 2022;17(6):e0270031. PMID 35714120. doi:10.1371/journal.pone.0270031
Reference: Bowman A, Scottish SPCA, Dowell FJ, Evans NP. ‘Four Seasons’ in an animal rescue centre; classical music reduces environmental stress in kennelled dogs. Physiol Behav 2015;143:70–82. PMID 25708275. doi:10.1016/j.physbeh.2015.02.035
Reference: Darabseh MZ, et al. Enhanced lung volumes and pressures in traditional wind instrument musicians: the case of the Mejwez. PLoS One 2026;21(3):e0344473. PMID 41785301. doi:10.1371/journal.pone.0344473
Reference: de Witte M, Spruit A, van Hooren S, Moonen X, Stams GJ. Effects of music interventions on stress-related outcomes: a systematic review and two meta-analyses. Health Psychol Rev 2020;14(2):294–324. PMID 31167611. doi:10.1080/17437199.2019.1627897
Reference: Espinosa N, et al. Neurobiological effects of music-making interventions for older adults: a systematic review. Aging Clin Exp Res 2025;37(1):113. PMID 40175615. doi:10.1007/s40520-025-03006-7
Reference: Feng Q, Wang L, Chen Y, … Rein G, … Bai X. Effects of different music on HEK293T cell growth and mitochondrial functions. Explore (NY) 2022;18(6):670–675. PMID 35248473. doi:10.1016/j.explore.2022.01.002
Reference: Goel N. Late-night presentation of an auditory stimulus phase delays human circadian rhythms. Am J Physiol Regul Integr Comp Physiol 2005;289(1):R209–R216. PMID 15790749. doi:10.1152/ajpregu.00754.2004
Reference: Goel N. An arousing, musically enhanced bird song stimulus mediates circadian rhythm phase advances in dim light. Am J Physiol Regul Integr Comp Physiol 2006;291(3):R822–R827. PMID 16614052. doi:10.1152/ajpregu.00550.2005
Reference: Hampton A, et al. J Feline Med Surg 2020;22(2):122–128. PMID 30744475. doi:10.1177/1098612X19828131
Reference: Kühlmann AYR, de Rooij A, Hunink MGM, De Zeeuw CI, Jeekel J. Music affects rodents: a systematic review of experimental research. Front Behav Neurosci 2018;12:301. PMID 30618659. doi:10.3389/fnbeh.2018.00301
Reference: Luquire K, McCully KK. Regional differences in mitochondrial capacity in the finger flexors of piano players. J Funct Morphol Kinesiol 2019;4(2):29. PMID 33467343. doi:10.3390/jfmk4020029
Reference: Marie D, Müller CAH, Altenmüller E, … James CE. Music interventions in 132 healthy older adults enhance cerebellar grey matter and auditory working memory, despite general brain atrophy. NeuroImage: Reports 2023;3(2):100166. PMID 40568451. doi:10.1016/j.ynirp.2023.100166
Reference: Marshall RL. Johann Sebastian Bach. Encyclopaedia Britannica (online; updated 25 Aug 2026).
Reference: McDermott JH, Schultz AF, Undurraga EA, Godoy RA. Indifference to dissonance in native Amazonians reveals cultural variation in music perception. Nature 2016;535(7613):547–550. PMID 27409816. doi:10.1038/nature18635
Reference: McNamara RJ, Epsley C, Coren E, McKeough ZJ. Singing for adults with chronic obstructive pulmonary disease (COPD). Cochrane Database Syst Rev 2017;12:CD012296. PMID 29253921. doi:10.1002/14651858.CD012296.pub2
Reference: Mehr SA, Singh M, Knox D, … Pinker S, … Glowacki L. Universality and diversity in human song. Science 2019;366(6468):eaax0868. PMID 31753969. doi:10.1126/science.aax0868
Reference: Mojtabavi H, Saghazadeh A, Valenti VE, Rezaei N. Can music influence cardiac autonomic system? A systematic review and narrative synthesis to evaluate its impact on heart rate variability. Complement Ther Clin Pract 2020;39:101162. PMID 32379689. doi:10.1016/j.ctcp.2020.101162
Reference: Schulze H-J; Brokaw JA II (trans./ed.). Commentaries on the Cantatas of J.S. Bach: An Interactive Companion. Illinois Open Publishing Network; 2024. doi:10.21900/wd.21
Reference: Wang X, Yamashita M, Guo X, Stiernman L, Kakihara M, Abe N, Sekiyama K. Never too late to start musical instrument training: effects on working memory and subcortical preservation in healthy older adults across 4 years. Imaging Neurosci (Camb) 2025;3:IMAG.a.48. PMID 40800951. doi:10.1162/imag.a.48
Reference: Wiśniewska M, et al. J Equine Vet Sci 2019;78:89–93. PMID 31203990. doi:10.1016/j.jevs.2018.12.011